METHODS AND COMPOSITIONS FOR PROLONGING SURVIVAL AFTER ORTHOPIC AND HETEROTOPIC TRANSPLANTATION OF XENOGENIC HEART, KIDNEY, LUNG OR LIVER Russian patent published in 2023 - IPC A61K31/436 A61K35/12 A61K48/00 A61K35/407 A61K35/42 A61K35/34 A61K35/22 A61P37/04 

FIELD: medicine.

SUBSTANCE: transplantation and immunology, intended for prolonging the survival of a recipient organism after transplantation. To prolong the survival of the recipient organism, which is transplanted with a genetically modified heart, kidney, lung or liver from a xenogeneic donor organism, an immunosuppressive maintenance therapeutic agent is administered to the recipient organism in accordance with the administration scheme; administering one or more antihypertensive agents to the recipient organism in accordance with the administration scheme; administration of an mTOR inhibitor to the recipient organism in accordance with the administration scheme. Then the dose of glucocorticoid administered to the recipient organism is reduced by at least 5 times within 5 days after transplantation. The donor organism is a primate. In other embodiments, the use of a composition containing an mTOR inhibitor and the use of a composition containing one or more antihypertensive agents in this method are provided.

EFFECT: ensuring the prolongation of the survival of the recipient organism after transplantation due to the prevention of the growth of the donor organ in the recipient organism.

33 cl, 25 dwg, 5 tbl, 7 ex