FIELD: medicine, immunology. SUBSTANCE: the method deals with transplantation in combination with one or several homologous complement restriction factors (HCRF), active in a recipient form, to prevent complete complement activation. HCRF represents or is of factor 1 activity (inactivator C3b or KAF), factor H, C4- binding protein, DAF (CD55), membranous cofactor protein (MCP, CD46, gp 45-70 or gp 66/56), CR1 (receptor C3b/C4b or CD35), CR2 (CD21, receptor C3.dg, receptor 3d/EBV and p140). Donor tissue could be transgenic and express HCRF-coding HK for a recipient during transplantation. To fulfill the method one should use a preparation being a homologous complement restriction factor (HCRF) active in a recipient form. Both the method and preparation enable to prevent the detachment of a transplant. EFFECT: higher efficiency. 17 cl, 22 dwg, 14 ex
Title |
Year |
Author |
Number |
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- Uajt Dehvid Dzhejms Grekhem
- Vill'Jams Alan Frederik
|
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- Van Khao
- Chzhun Chzhen'
|
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|
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- Fehrriz Timoti Charl'Z
|
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- Suzuki Sejiti
- Isobe Mitsuaki
|
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|
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|
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- Bakh Fritts Kh.
- Tobiash Ehdda M.
- Soarez Migel' K.
- Otterbajn Leo Eh.
- Gous Dzhinn
|
RU2376997C2 |
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1995 |
- Noelle Randol'F Dzh.
- D'Juri Fiona Kh.
- Parker Dehvid S.
- Ehppel Majkl S.
- Filips Nehnsi E.
- Mordes Dzhon P.
- Grenajr Dehjl L.
- Rossini Aldo A.
|
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|
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