FIELD: biotechnology.
SUBSTANCE: invention relates to the production of a lyophilized pharmaceutical composition, and can be used in medicine for the treatment of neuropathy. The composition contains an effective amount of plasmid DNA expressing two isoforms of the human HGF protein, potassium phosphate buffer, mannitol, sucrose and sodium chloride.
EFFECT: invention makes it possible to obtain a lyophilized pharmaceutical composition that retains the stability of a DNA plasmid during lyophilization and pharmaceutical activity for genetic therapy after its re-dissolution in water.
11 cl, 55 dwg, 44 tbl, 4 ex
| Title |
Year |
Author |
Number |
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2019 |
- Li, Dzhunkhun
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|
RU2781980C2 |
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2017 |
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2018 |
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2019 |
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|
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| COMBINATION DRUG CONTAINING CORTICOSTEROID AND EXOSOMES |
2010 |
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| PHARMACEUTICAL PREPARATION CONTAINING RECOMBINANT HCG (HUMAN CHORIONIC GONADOTROPIN HORMONE) |
2010 |
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| RECOMBINANT VACCINE AGAINST VARICELLA ZOSTER VIRUS (VZV) |
2020 |
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|
RU2772902C1 |
| GENETIC CONSTRUCT |
2016 |
- Viddouson, Piter
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|
RU2734678C2 |
| CHIMERIC PROTEIN, A SYNTHETIC DNA WHICH CODES SAID PROTEIN, AN EXPRESSION VECTOR, A SYNTHETIC DNA PRODUCING STRAIN AND A METHOD OF PRODUCING PLASMID DNA |
2016 |
- Dukhovlinov Ilya Vladimirovich
|
RU2736472C2 |
