FIELD: medicine.
SUBSTANCE: group of inventions relates to a method for treating a subject suffering from cancer using an immunoconjugate comprising an antibody conjugated to a medicinal product component, where the medicinal product component has the structure shown in Formula (I) below:
(I), where Ab in Formula (I) is an antibody and where the heavy chain and light chain of the antibody comprise the amino acid sequences of SEQ ID NO: 1 and 2, respectively ; and wherein the immunoconjugate is administered to a subject at a dose of 0.25 to 4.00 mg/kg, also refers to an immunoconjugate for use in the treatment of cancer in a subject in a method for treating a subject with cancer, and to the use of an immunoconjugate for the preparation of a medicament for the treatment of cancer in a subject in a method of treating a subject suffering from cancer.
EFFECT: group of inventions provides for the development of a new therapy for patients with hematological malignancies and other malignant diseases which improves outcomes for patients, including patients who do not respond to existing therapies, by targeting ROR1.
19 cl, 5 dwg, 8 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHODS OF TREATING USING ANTI-CD123 IMMUNOCONJUGATES | 2019 |
|
RU2816847C2 |
| COMPOSITIONS OF ANTIBODIES AGAINST ROR1 AND CORRESPONDING METHODS | 2017 |
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|
RU2801307C1 |
| NK INVOLVING MOLECULES AND METHODS OF THEIR USE | 2019 |
|
RU2812481C2 |
| MULTI-SPECIFIC ANTIBODIES AND METHODS OF THEIR PRODUCTION AND USE | 2018 |
|
RU2811477C2 |
| ANTIBODY-DRUG CONJUGATES CONTAINING HERBOXYDIENE-BASED SPLICING MODULATOR, AND METHODS OF USE THEREOF | 2019 |
|
RU2820607C2 |
| ANTIBODIES AGAINST CD79b, DRUG CONJUGATES AND THEIR USE | 2019 |
|
RU2805251C2 |
| METHODS FOR MODULATING CART-CELLS | 2017 |
|
RU2774232C2 |
