METHODS AND COMPOSITIONS FOR ADMINISTRATION OF DOSES OF ALLOGENEIC T-CELLS WITH CHIMERIC ANTIGEN RECEPTOR Russian patent published in 2022 - IPC C12N5/783 A61K35/17 A61P35/00

Abstract RU 2776322 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular to a method for the treatment of a subject, providing the administration to the subject of at least one dose of allogeneic T-cells with a chimeric antigen receptor (hereinafter – CAR) (CAR-T-cells), containing CAR 4-1BB/CD3-zeta for human CD19, where at least one dose is from about 20×10⁶ cells/dose to about 360×10⁶ cells/dose.

EFFECT: invention is effective for the treatment of refractory and/or recurrent non-Hodgkin’s lymphoma.

39 cl, 14 dwg, 13 tbl, 5 ex

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RU 2 776 322 C2

Authors

Konto, Cyril Alkis

Zinai, Amina

Dates

2022-07-18—Published

2018-10-30—Filed