FIELD: biotechnology.
SUBSTANCE: invention relates to polypeptides with protease activity, and can be used to obtain recombinant immunoglobulins. Proposed polypeptides with protease activity of the enzyme that destroys immunoglobulin, Streptococcus pyogenes (IdeS).
EFFECT: production of polypeptides capable of cleaving a target protein with an Fc domain, such as aflibercept, into fragments.
18 cl, 59 dwg, 9 tbl, 9 ex
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