PHARMACEUTICAL COMPOSITION FOR PREVENTION OF EPIDURAL FIBROSIS AND METHOD OF ITS USE Russian patent published in 2023 - IPC A61K31/787 A61K47/38 A61K47/58 A61P41/00 

FIELD: medicine.

SUBSTANCE: group of inventions refers to pharmaceutical compositions and a method for preventing epidural fibrosis. Pharmaceutical compositions are: 77 parts 8% polyacrylamide solution, 20 parts 0.05% p38 MAP kinase blocker SB203580 hydrochloride solution, 5 parts glycerol and 2 parts Tween-80, pH adjusted to 7.6 with 0.1 M NaOH; 73.5 parts 5% polyacrylamide, 20 parts 0.025% p38 MAP kinase blocker SB239063 in DMSO, 5 parts glycerol, and 2 parts Tween-80, pH adjusted to 7.6 with 0.1 M NaOH; 70 parts 10% polyacrylamide solution, 8 parts 0.005% p38 MAP kinase blocker SB203580 hydrochloride solution, 7 parts glycerol and 1 part Tween-80, pH adjusted to 7.6 with 0.1 M NaOH; 70 parts 10% polyacrylamide, 18 parts 0.0005% p38 MAP kinase blocker VX-745 in DMSO, 7 parts glycerol, and 1 part Tween-80, pH adjusted to 7.6 with 0.1 M NaOH. The preventive method consists in the introduction of a pharmaceutical composition into the area of laminectomy during surgery in the form of a sterile gel.

EFFECT: group of inventions described above makes it possible to prevent the development of epidural fibrosis in the area of surgical intervention.

5 cl, 6 dwg, 8 ex