COMPOSITION FOR PREVENTION OF CICATRICIAL-ADHESIVE COMPLICATIONS IN CARDIOSURGERY AND METHOD OF APPLICATION THEREOF Russian patent published in 2025 - IPC A61K31/4439 A61K31/505 A61K47/02 A61K47/10 A61K47/32 A61P41/00 

FIELD: chemistry; medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to chemistry, medicine and pharmaceutics, namely to a composition for preventing cicatricial-adhesive complications in cardiac surgery and to a method of using it for preventing cicatricial-adhesive complications in cardiac surgeries in a subject in need. Disclosed composition contains the following, wt.%: 3.1–8.0 of polyvinyl alcohol; 0.008–0.02 of polyvinylimidazole; 0.00065–0.002 of p38 MAP kinase blocker which is SB203580, SB239063, VX-745 or AL 8697; 7.7–13.3 of glycerol; purified water to 100.0, wherein the pH of composition is 7.2–7.6. According to the proposed method, the above composition is introduced once in the form of a sterile gel into the injured area during a surgical intervention.

EFFECT: group of inventions provides preventing the formation of postoperative adhesions in the pericardial cavity, as well as maintaining the stability of the properties of the composition during prolonged storage (12 months and more).

3 cl, 5 dwg, 1 tbl, 9 ex