NALMEFEN, NALTREXONE OR DERIVATIVES THEREOF FOR USE IN TREATING (NON)-ALCOHOLIC STEATOHEPATITIS OR NON-ALCOHOLIC FATTY LIVER DISEASE Russian patent published in 2020 - IPC A61K31/485 A61P1/16 C07D491/48 

Abstract RU 2717677 C1

FIELD: chemistry.

SUBSTANCE: invention relates to use of the compound of formula (I) for preventing or treating non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) or alcoholic steatohepatitis (ASH), where A is OH or OCH3; R represents H, CH3 or cyclopropylmethyl; X is an oxygen atom, Y is CH2 or oxygen, Z is H or OH, and where the use of the compound of formula (I) leads to reduced hepatic fibrosis, which is a sign of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) or alcoholic steatohepatitis (ASH).

(I).

EFFECT: technical result is the possibility of using the compound of formula (I) for preventing or treating non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) or alcoholic steatohepatitis (ASH).

14 cl, 1 tbl, 7 dwg, 4 ex

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RU 2 717 677 C1

Authors

Wu, Edwin, Sc

Chiu, Peter, J.S.

Hsu, May, Mei-Chi

Dates

2020-03-25Published

2017-04-20Filed