FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, namely to combination therapy with a chemokine receptor 2 (CCR2) antagonist and a PD-1 and/or PD-L1 inhibitor in the treatment of colorectal cancer. A method for enhancing the therapeutic effect of a PD-1 and/or PD-L1 inhibitor in the treatment of colorectal cancer in a mammal is proposed, the said method includes administering a therapeutically effective amount of a CCR2 chemokine receptor antagonist and a therapeutically effective amount of a PD-1 and/or PD-L1 inhibitor to a mammal. Also the following is provided: the use of a therapeutically effective amount of a CCR2 chemokine receptor antagonist to enhance the therapeutic effect of a PD-1 and/or PD-L1 inhibitor in the treatment of colorectal cancer in a subject, and a kit comprising a therapeutically effective amount of a CCR2 chemokine receptor antagonist, a therapeutically effective amount of a PD-1 inhibitor, and/or PD-L1 and instructions for use.
EFFECT: provision of a significant reduction in tumor size.
25 cl, 14 dwg, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMBINATION THERAPY USING CC CHEMOKINE RECEPTOR 4 (CCR4) ANTAGONISTS AND ONE OR MORE CHECKPOINT INHIBITORS | 2019 |
|
RU2810717C2 |
| REDUCTION OF TUMOR MASS BY INJECTING CCR1 ANTAGONISTS IN COMBINATION WITH PD-1 INHIBITORS OR PD-L1 INHIBITORS | 2017 |
|
RU2745195C2 |
| METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS | 2014 |
|
RU2825390C2 |
| COMPOSITIONS FOR TREATING CANCER USING ANTAGONISTS WHICH BIND TO THE PD-1 SIGNALING PATHWAY COMPONENT AND MEK INHIBITORS | 2015 |
|
RU2733735C2 |
| MODULATORS CCR2 | 2016 |
|
RU2726206C2 |
| METHODS OF TREATING CANCER USING ANTAGONISTS BINDING TO PD-1 AXIS AND TIGIT INHIBITORS | 2014 |
|
RU2702108C2 |
| STABLE LOCAL DRUG LEVELS FOR INNATE IMMUNITY AGONISTS | 2020 |
|
RU2817710C2 |
| COMBINATIONS OF DUAL MODULATORS IRS/STAT3 AND ANTIBODIES TO PD-1/PD-L1 FOR CANCER TREATMENT | 2017 |
|
RU2796275C2 |
| SOLUBLE C5aR ANTAGONISTS | 2017 |
|
RU2748260C2 |
| METHODS OF TREATING CANCER USING PD-1 AND PD-L1 ANTAGONISTS IN COMBINATION WITH RADIATION THERAPY | 2015 |
|
RU2711408C2 |
