FIELD: pharmaceutical industry.
SUBSTANCE: group of inventions relates to a method of treating a malignant neoplasm in a mammal, including the administration of an effective amount of an antagonist of CC chemokine receptor 4 (CCR4 antagonist) and an antibody to cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4 antibody); and also to the use of a combination of a CCR4 antagonist and an anti-CTLA-4 antibody as therapeutic agents in the said method of treatment. In the proposed method and use of CCR4, the antagonist is compound 1.
EFFECT: group of inventions provides increased efficiency in the treatment of malignant neoplasms compared to one or more checkpoint inhibitors used separately.
11 cl, 26 dwg, 2 tbl, 4 ex
| Title |
Year |
Author |
Number |
| COMBINATION THERAPY WITH A CHEMOKINE RECEPTOR 2 (CCR2) ANTAGONIST AND A PD-1/PD-L1 INHIBITOR |
2018 |
- Campbell, James J.
- Miao, Zhenhua
- Schall, Thomas J.
- Charo, Israel
- Li, Shijie
- Janson, Christine Marie
- Singh, Rajinder
- Ebsworth, Karen
|
RU2796863C2 |
| REDUCTION OF TUMOR MASS BY INJECTING CCR1 ANTAGONISTS IN COMBINATION WITH PD-1 INHIBITORS OR PD-L1 INHIBITORS |
2017 |
- Sharo Izrael
- Chon Khejyun
- Shall Tomas Dzh.
- Chzhan Penli
|
RU2745195C2 |
| CANCER CHEMOTHERAPY USING AZABICYCLO COMPOUND |
2018 |
|
RU2821034C2 |
| METHODS OF TREATMENT |
2020 |
|
RU2822394C1 |
| COMPOSITIONS FOR TREATING CANCER USING ANTAGONISTS WHICH BIND TO THE PD-1 SIGNALING PATHWAY COMPONENT AND MEK INHIBITORS |
2015 |
|
RU2733735C2 |
| COMBINATION THERAPY FOR TREATING CANCER WITH POXVIRUS EXPRESSING TUMOUR ANTIGEN AND ANTAGONIST AND/OR AGONIST OF IMMUNE CHECKPOINT INHIBITOR |
2014 |
- Rauntri, Rajan
- Foj, Syuzan
- Mendl, Stefani
- Delker, Alen
|
RU2714142C2 |
| COMBINED TREATMENT OF MALIGNANT NEOPLASM USING SULPHONAMIDE COMPOUND AND IMMUNOREGULATOR |
2020 |
- Ueno, Hiroyuki
- Tsukioka Sayaka
|
RU2820817C2 |
| THIOCARBAMATE DERIVATIVES AS A2A INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS THEREOF WITH ANTICANCER AGENTS |
2019 |
- Crosignani, Stefano
- Dickinson, Paul
- De Matas, Marcel
- Houthuys, Erica Joke Katelijne Heleen
- Marillier, Reece Gerrad
- Martinoli, Chiara
- De Henau, Olivier
- Driessens, Gregory
|
RU2824502C2 |
| COMBINED THERAPY WITH TETRACYCLIC QUINOLONE ANALOGUES FOR CANCER TREATMENT |
2016 |
|
RU2752506C2 |
| COMBINATION THERAPY WITH TETRACYCLIC QUINOLONE ANALOGUES FOR TREATMENT OF CANCER |
2016 |
|
RU2786570C2 |
