NEW PYRIDINE AND PYRAZINE COMPOUNDS AS CANNABINOID RECEPTOR 2 INHIBITORS Russian patent published in 2023 - IPC C07D401/04 A61K31/4427 A61K31/4439 A61P23/02 A61P27/06 A61P29/00 A61P9/00

Abstract RU 2797345 C2

FIELD: organic chemistry.

SUBSTANCE: invention relates to a compound of formula (I) and its pharmaceutically acceptable salt, which have modulating activity against the cannabinoid CB2 receptor. In this formula, R¹ is C_1-6 alkoxyazetidinyl, dihalogenazetidinyl or pyrrolidinyl; R² and R³ are independently selected from hydrogen and C_1-4 alkyl; A¹ represents -CH-; A² represents -CH₂ - or carbonyl; X represents a fluorine atom; n is 1–3; and m is 0.

EFFECT: invention also relates to specific compounds of formula (I), a method for preparing a compound of formula (I) and a pharmaceutical composition that modulates the activity of the cannabinoid CB2 receptor and contains an effective amount of a compound of formula (I).

6 cl, 1 tbl, 40 ex

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RU 2 797 345 C2

Authors

Gobbi, Luka

Greter, Uve

Krets, Yulian

Ametamej, Sajmon, M.

Dates

2023-06-02—Published

2019-06-25—Filed