FIELD: medicine.
SUBSTANCE: group of inventions includes prodrugs of opioid receptor antagonists of the formula:
,
where X represents O or CH2 or their pharmaceutically acceptable salts. The group of inventions also relates to a pharmaceutical composition containing the said prodrugs, a method for treating opioid dependence, and the use of the pharmaceutical composition.
EFFECT: provision of opioid receptor antagonists that provide long-term, delayed and controlled release of nalmefene and naltrexone opioid receptor antagonists when administered.
14 cl, 101 tbl, 49 dwg, 73 ex
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