PRODRUGS OF OPIOID RECEPTOR ANTAGONISTS Russian patent published in 2022 - IPC C07D489/08 A61K31/485 A61P25/32 A61P25/36 

Abstract RU 2785777 C2

FIELD: medicine.

SUBSTANCE: invention relates to compounds or their pharmaceutically acceptable salts having structures represented below, where X is O or CH2. The invention also relates to a pharmaceutical composition for the treatment of opioid addiction, based on the specified compounds.

EFFECT: new compounds and a pharmaceutical composition based on them are obtained, which provide long-term, slowed down, and controlled release of antagonists of opioid nalmefene and naltrexone receptors, when administered to the body.

15 cl, 34 dwg, 31 tbl, 35 ex

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RU 2 785 777 C2

Authors

Shakh, Nikezh

Tusche, Majkl V.

Dzhi, Liangliang

Ding, Mingping

Khan, Tsyan

Dates

2022-12-13Published

2018-11-03Filed