NEW DERIVATIVES OF 3,5-DISUBSTITUTED PYRIDINE AND 3,5-DISUBSTITUTED PYRIDAZINE AND THEIR PHARMACEUTICAL USE Russian patent published in 2023 - IPC C07D213/65 C07D237/08 C07D237/14 C07D401/04 C07D413/04 C07D413/14 A61K31/4412 A61K31/4418 A61K31/4439 A61K31/444 A61P35/00 A61P11/00 A61P13/00 A61P13/08 A61P17/00 A61P19/02 A61P25/04 A61P27/00 A61P27/02 A61P29/00 A61P3/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (1) having an inhibitory effect on autotaxin or a pharmacologically acceptable salt thereof, a pharmaceutical composition based on them, a method for treating a disease in which autotaxin is involved, as well as their use in the manufacture of an agent for treating a disease, in which autotaxin is involved. In the general formula (1) where R¹ represents

,

where X^1a represents -C(R^1a)₂ - or -NR^1b -, X^1b and X^1c are the same or different, and each represents -O- or -CH₂-, R^1c represents a hydrogen atom, a halogen atom, C₁-C₂ perfluoroalkyl, C₁-C₂ perfluoroalkoxy or C₁-C₂ perfluoroalkylthio, R^1d is a hydrogen atom, a halogen atom or C₁-C₆ alkyl, and R^1e is C₁-C₂ perfluoroalkoxy, X is -N= or -CH=, ring A is ,

L is -(CHR^3a)_n-, where n is 0, 1, 2 or 3, the multiple symbols of R^3a are the same or different, and each represents a hydrogen atom or C₁-C₆ alkyl, -(CH₂)_m -O-(CH₂)_m'-, where each m and m' is 1, C₂-C₃ alkenylene,

.

The remaining values of the radicals are indicated in the claims.

EFFECT: development of compounds having an inhibitory effect on autotaxin.

28 cl, 8 dwg, 26 tbl, 101 ex