AMINOPIRIDAZINOVE COMPOUNDS AS PROTEINKINASE INHIBITORS Russian patent published in 2018 - IPC C07D237/00 C07D487/04 A61K31/50 A61K31/505 A61P35/00 A61P25/00

Abstract RU 2674701 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: present invention relates to a compound of general formula (I) or a pharmaceutically acceptable salt , where A, R^a, R^b, R^c, R^d, B, L, Y have the meanings indicated in point 1 of the formula of the invention. Also disclosed a pharmaceutical composition that have inhibitory activity against protein tyrosine kinase, containing the above compound, method of modulating the activity of a protein tyrosine kinase and a method of treating a condition or a disease transmitted by a protein tyrosine kinase, using the above compound.

EFFECT: obtaining new compounds that exhibit a strong inhibitory effect against Bruton's tyrosine kinase, and therefore can provide potential treatment strategies for human carcinoma, including B-cell lymphoma, and autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis.

39 cl, 2 dwg, 6 tbl, 118 ex

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RU 2 674 701 C2

Authors

Lyu Dun

Chzhan Minshen

Khu Tsiyue

Dates

2018-12-12—Published

2014-10-20—Filed