METHOD FOR PREDICTION OF DEVELOPMENT OF ASCITES IN LIVER CIRRHOSIS Russian patent published in 2025 - IPC A61B5/00 G01N33/49 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to gastroenterology and hepatology. Blood serum is analyzed, as well as bioimpedance analysis of human body composition, anthropometric measurements, on the basis of which the values are determined. Patient’s blood serum is analyzed for: erythrocyte count, ×10¹²/l; total bilirubin level, mcmol/l; albumin level, g/l; INR level. By means of bioimpedance analysis of human body composition the following is determined: phase angle (PA), degrees; fat-free body weight (FFBW), kg; fraction (%) of active cell mass (ACM), defined as percentage of ACM in FFBW, % ACM = (100 × ACM / FFBW)%. By means of anthropometric measurements: fat deposition index (FDI) is determined as: FDI = hip girth, cm/body length, m. Obtained values of seven parameters are assigned with points: if FDI is less than 27.9, 2 points are assigned, FDI 28 and more: 4 points; if there is a share of ACM of 50% or more, 2 points are assigned, share of ACM 49% and less: 4 points; in the presence of PA 6° and more are assigned 2 points, with PA 5° and less: 4 points; in the presence of an erythrocyte count of 4.1 × 10¹²/l and more are assigned 2 points, 4.0 × 10¹²/l and less: 4 points; in the presence of total bilirubin from the range of values of 30 and less mcmol/l, 2 points are assigned, from range of 31–60 mcmol/l: 4 points, if value is 61 and more mcmol/l: 6 points; if the albumin level is 35 g/l and more, 3 points are assigned, if value is 34 g/l and less: 6 points; if the INR level is 1.2 or less, 2 points are assigned, and if value is 1.3 or more, 4 points are assigned. Obtained points are summed up. Prognosis of developing ascites within a year in cirrhosis (P) is determined by formula: P=∑F_i /32*100%, where ∑F_i is the sum of points for each indicator, i = from 1 to 7. If the P value is 66% or less, the minimum risk of developing ascites is predicted for a year in cirrhosis, while the P value of 67% and more shows a high risk.

EFFECT: method enables predicting the development of ascites for a year in liver cirrhosis based on taking into account a complex of diagnostically significant parameters - data of bioimpedance analysis of body composition and laboratory data of the patient.

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