METHOD OF PREDICTING THE DEVELOPMENT OF RELAPSE IN PATIENTS WITH HUMAN PAPILLOMAVIRUS AND NON-MUSCLE-INVASIVE BLADDER CANCER Russian patent published in 2023 - IPC C12Q1/00 C12Q1/68 C12Q1/6876 C12Q1/6886 

FIELD: molecular biology.

SUBSTANCE: method of predicting the development of recurrence of non-muscle-invasive bladder cancer in patients with human papillomavirus is described, in which highly specific primers for hsa-miR-7-5p and hsa-miR-143-3p are used. When implementing the method, amplification is carried out, primary data are analyzed and the coefficient of relative expression K is calculated, the obtained values of K are compared with the interval of the prognostic coefficient. With a value of K_miR-143≤ 5.07*10^-3 the development of recurrence of non-muscle-invasive bladder cancer is predicted in the first 18 months after transurethral resection of the bladder. With a value of K_miR-143≥ 20.09*10^-3 the course of the disease without recurrence is predicted, and with the values of the coefficient K between the indicated intervals, the result is considered uncertain.

EFFECT: creation of a method of predicting the recurrence of non-muscle-invasive bladder cancer in the first 18 months after transurethral resection (TUR) of the bladder in patients with HPV.

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