FIELD: molecular biology.
SUBSTANCE: method of predicting the development of recurrence of non-muscle-invasive bladder cancer in patients with human papillomavirus is described, in which highly specific primers for hsa-miR-7-5p and hsa-miR-143-3p are used. When implementing the method, amplification is carried out, primary data are analyzed and the coefficient of relative expression K is calculated, the obtained values of K are compared with the interval of the prognostic coefficient. With a value of KmiR-143≤ 5.07*10-3 the development of recurrence of non-muscle-invasive bladder cancer is predicted in the first 18 months after transurethral resection of the bladder. With a value of KmiR-143≥ 20.09*10-3 the course of the disease without recurrence is predicted, and with the values of the coefficient K between the indicated intervals, the result is considered uncertain.
EFFECT: creation of a method of predicting the recurrence of non-muscle-invasive bladder cancer in the first 18 months after transurethral resection (TUR) of the bladder in patients with HPV.
3 cl, 2 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| TEST SYSTEM “miR-M-SCREEN” FOR PREDICTING THE DEVELOPMENT OF METASTASES IN PATIENTS WITH COLORECTAL CANCER BASED ON THE LEVEL OF miR-26a AND miR-143 MICRO-RNA IN BLOOD PLASMA | 2022 |
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| SET OF OLIGODEOXYRIBONUCLEOTIDE PRIMERS FOR DIAGNOSING CARDIOVASCULAR DISEASES AND DETECTING RISK OF THEIR DEVELOPMENT BASED ON BIOMOLECULAR MARKER microRNA hsa-miR-143-5p BY QUANTITATIVE PCR AND USE THEREOF | 2025 |
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RU2838258C1 |
