METHOD FOR DIFFERENTIAL DIAGNOSIS OF OVARIAN CANCER, OVARIAN CYSTIC GROWTHS AND UTERINE CANCER Russian patent published in 2025 - IPC G01N33/58 C12Q1/6806 C12Q1/686 C12Q1/6876 C12Q1/6886 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology, and can be used for differential diagnosis of ovarian cancer, ovarian cystic growths and uterine cancer. In urine determined are micro-RNA transcripts hsa-miR-33b-5p, hsa-miR-423-5p and hsa-miR-7-5p. Calculated are relative expression coefficients of micro-RNA hsa-miR-33b-5p (Khsa-miR-33b-5p) and hsa-miR-423-5p (Khsa-miR-423-5p) as ratio of relative expression hsa-miR-33b-5p and hsa-miR-423-5p relative to reference micro-RNA hsa-miR-7-5p. At values Khsa-miR-33b-5p ≤ 1.04*10^-7 and Khsa-miR-423-5p ≤ 3.01*10^-7, ovarian cancer is diagnosed. At values Khsa-miR-33b-5p ≥ 4.71*10^-7 and Khsa-miR-423-5p ≥ 5.11*10^-7, ovarian cystic growths are diagnosed. At values Khsa-miR-33b-5p ≥ 12.47*10^-5 and Khsa-miR-423-5p ≤ 0.18*10^-9, uterine cancer is diagnosed. If the coefficient K is between the above intervals, the obtained result is considered to be uncertain.

EFFECT: method provides non-invasive diagnosis of ovarian cancer, ovarian cystic growths and uterine body cancer by determining micro-RNA transcripts in urine.

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