METHOD OF ASSESSING COMPLIANCE WITH A GLUTEN-FREE DIET IN PATIENTS WITH GLUTEN-SENSITIVE CELIAC DISEASE Russian patent published in 2023 - IPC G01N33/68 G01N33/564 

FIELD: medicine, gastroenterology.

SUBSTANCE: invention can be used to assess compliance with a gluten-free diet in patients with gluten-sensitive celiac disease by examining blood and feces. Zonulin in feces and Fatty-Acid-Binding Protein-I (I-FABP) in blood serum are determined. If the level of zonulin is 90.6–111.6 ng/ml and the content of I-FABP is 1,406–2,045 pg/ml, compliance with the gluten-free diet is assessed as non-strict. When the level of zonulin is 55.0–90.5 ng/ml and the content of I-FABP is 900–1,000 pg/ml, adherence to the gluten-free diet is assessed as strict.

EFFECT: method provides an opportunity to increase the efficiency of assessing the dynamics of the course of gluten-sensitive celiac disease by determining the level of serum I-FABP and fecal zonulin in patients with celiac disease.

1 cl, 2 dwg, 2 tbl, 2 ex