METHOD OF FORMING POST-VACCINATION IMMUNE AGAINST INFLUENZA VIRUS IN PATIENTS WITH GENERAL VARIABLE IMMUNE DEFICIENCY Russian patent published in 2023 - IPC A61K39/145 A61K31/787 A61P31/16 A61K45/06 

FIELD: virology.

SUBSTANCE: invention relates to a method of the formation of post-vaccination immunity against the influenza virus in patients with common variable immunodeficiency including simultaneous administration to the subject of two doses of 0.5 ml of an inactivated polymer-subunit adjuvant vaccine containing 5 μg of protective antigens of epidemically relevant strains of influenza viruses of type A of subtypes A(H1N1), A(H3N2), type B, and 500 µg of azoximer bromide.

EFFECT: invention ensures the development of high immunogenicity in patients with common variable immunodeficiency (CVID) after simultaneous administration of two doses of a subunit adjuvant influenza vaccine, while the proportion of patients with a 2-fold or more increase in antibody titer 3–4 weeks after simultaneous vaccination with two doses of vaccination 9.3 times higher compared to vaccination with a single dose, also provides an increase in the proportion of granulocytes, lymphocytes expressing TLR9, and on monocytes — TLR3 and TLR9, which play a key role in the elimination of microbial agents through the recruitment of phagocytes or activation of dendritic cells, also provides a high safety profile of tri- and quadrivalent adjuvant vaccines in patients with CVID.

1 cl, 19 dwg, 6 ex, 11 tbl