RECOMBINANT ANTI-INFLUENZA VACCINE WITH WIDE RANGE OF PROTECTION AND METHOD FOR ITS PREPARATION Russian patent published in 2021 - IPC A61K39/145 A61P31/16 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine, namely to a recombinant protein molecule intended for the preparation of a vaccine against influenza, an amino acid sequence of which includes an amino acid sequence of flagellin of Salmonella typhimurium bacterium, to the C-end of which an amino acid sequence of a conservative fragment of the second subunit of hemagglutinin of influenza viruses of the first phylogenetic group RLENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRMQLRDNA is attached, or an amino acid sequence of a conservative fragment of the second subunit of hemagglutinin of influenza viruses of the second phylogenetic group RIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENA is attached, and includes 2 copies of an amino acid sequence of M2e peptides of a human influenza A virus SLLTEVETPIRNEWGCRCNDSSD and 2 copies of an amino acid sequence of M2e peptides of H1N1pdm09 virus SLLTEVETPTRSEWECRCSDSSD, as well as glycine-rich linkers connecting the above-mentioned elements, as well as relates to a candidate vaccine against the infection caused by an influenza virus including a recombinant protein molecule.

EFFECT: group of inventions provides for an increase in immunogenicity of the anti-influenza vaccine and an expansion of the protection range.

2 cl, 9 dwg, 7 ex