PERI-SUBSTITUTED ARYLSULPHONAMIDE BICYCLIC COMPOUNDS FOR TREATING ARTERY OCCLUSIVE DISEASES Russian patent published in 2010 - IPC C07D209/08 C07D409/12 C07D409/14 C07D413/04 C07D413/14 A61K31/404 A61P9/10 

FIELD: chemistry.

SUBSTANCE: in compounds of formula:

, A and B denote a pair of condensed saturated or unsaturated 5- or 6-member rings, where the said system of condensed rings A/B contains 0-2 nitrogen atoms, and said rings are further substituted with 0-4 substitutes independently selected from halogen, lower alkyl or oxo; and a and b are bonding positions for residues Y and D, respectively, and these positions a and b are in the peri-position relative each other on the said condensed ring system A/B; d and e are condensed positions between ring A and ring B in the said condensed ring system A/B; D is an aryl or heteroaryl cyclic system which denotes a 5- or 6-member aromatic ring containing 0-3 heteroatoms selected from O, N or S; which can be further substituted with 0-4 substitutes independently selected from lower alkyl and amine; Y is selected from -CH₂ and -O-; M is selected from aryl, aryl substituted with a halogen or alkoxy; R¹ is selected from aryl, aryl substituted with a halogen, heteroaryl, heteroaryl substituted with a halogen, where heteraryl denotes a 5- or 6-member aromatic ring containing 0-3 heteroatoms selected from O, N or S, and CF₃; and if Y denotes -CH₂- or -O-, then R¹ further denotes a lower alkyl. The invention also pertains to use of compounds in claim 1, a pharmaceutical composition, a screening method on selective ligands of prostanoid receptors, as well as compounds of the formula.

EFFECT: obtaining novel biologically active compounds for inhibiting binding of prostanoid E₂ with EP3 receptor.

25 cl, 46 ex