ANTIBODIES TARGETING BONE Russian patent published in 2023 - IPC C07K16/22 C12N15/13 C12N15/63 A61K39/395 A61P19/08 

Abstract RU 2801206 C2

FIELD: biotechnology.

SUBSTANCE: bone-targeted antibody containing a heavy chain and a light chain that specifically binds to TGFβ1, TGFβ2 and TGFβ3 is suggested. The antibody is modified with one or more polyaspartic acid peptides to improve the localization of the antibody in the bone. Also the methods of making and using the said antibody to treat a human with bone disease are disclosed.

EFFECT: invention provides improved efficacy in the treatment of pathophysiological bone degeneration while minimizing potential adverse side effects.

22 cl, 47 dwg, 11 tbl, 21 ex

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RU 2 801 206 C2

Authors

Qiu, Huawei

Park, Sunghae

Stefano, James

Dates

2023-08-03Published

2018-01-19Filed