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(19)

(11)

2 764 559

(13)

(51)

IPC

C07K16/28(2006-01-01)

C12P21/08(2006-01-01)

C12N5/10(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

A61K39/395(2006-01-01)

(21) (22)

Application

2020115037, 2018-10-01

(24)

Start date

2018-10-01

(22)

Actual filing date

2018-10-01

(45)

Published

2022-01-18

(72)

Inventor

Brak, Simon SebastyanAttinger-Toller, IzabellaBiller, FabianGrabulovski, DraganBertsinger, YulianZumsteg, Adrian

(73)

Holder

Tsilag Gmbkh Interneshnl

MUTANT VARIANTS OF Fc IgG1 DEVOID OF EFFECTOR FUNCTIONS Russian patent published in 2022 - IPC C07K16/28 C12P21/08 C12N5/10 C12N15/13 C12N15/63 A61K39/395

Abstract RU 2764559 C2

FIELD: biotechnology.

SUBSTANCE: presented are: a therapeutic recombinant molecule containing human Fc IgG1, containing a CH2 domain, as well as an application thereof for treating various diseases, a recombinant polynucleotide encoding the molecule, an expression vector, a host cell, methods for producing the recombinant molecule, a recombinant polypeptide, a pharmaceutical composition, a method for treating a disease or disorder.

EFFECT: new molecules containing Fc with modifications in the Fc region with reduced binding to C1q and Fc gamma receptors allow for application thereof in treatment of cancer.

22 cl, 10 dwg, 5 tbl, 10 ex

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RU 2 764 559 C2

Authors

Brak, Simon Sebastyan

Attinger-Toller, Izabella

Biller, Fabian

Grabulovski, Dragan

Bertsinger, Yulian

Zumsteg, Adrian

Dates

2022-01-18—Published

2018-10-01—Filed