FIELD: biotechnology.
SUBSTANCE: continuous methods of preparing an antibody-drug conjugate (ADC) composition are provided. These methods use continuous conjugation processes, single pass tangential flow filtration, countercurrent diafiltration and/or inline process automation technologies.
EFFECT: methods reduce the time and cost of the processes and improve the stability of the product.
45 cl, 14 dwg, 8 tbl, 9 ex
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