ANTI-HER2 BIPARATOPIC ANTIBODY-DRUG CONJUGATES AND METHODS OF THEIR APPLICATION Russian patent published in 2023 - IPC C07K16/46 C07K16/28 C07K16/32 A61K47/65 A61K47/68 A61P35/00 

Abstract RU 2806049 C2

FIELD: biotechnology.

SUBSTANCE: group of inventions is described, including an anti-HER2 antibody-drug conjugate (variants), a pharmaceutical composition for the treatment of HER2-expressing cancer, including the above-mentioned anti-HER2 antibody-drug conjugate, a method of treating HER2-expressing cancer, including the administration of an effective amount of anti- HER2 antibody-drug conjugate, and the use of an anti-HER2 antibody-drug conjugate in the production of a drug for the treatment of HER2-expressing cancer. In one embodiment, the anti-HER2 antibody-drug conjugate comprises a biparatopic antibody conjugated to an auristatin analog via a linker and with a low average drug to antibody ratio.

EFFECT: invention expands the arsenal of anti-HER2 agents.

36 cl, 18 dwg, 28 tbl, 12 ex

Similar patents RU2806049C2

Title Year Author Number
BISPECIFIC ANTIGEN-BINDING CONSTRUCTS AGAINST HER2 2014
  • Weisser Nina E.
  • Ng Gordon Yiu Kon
  • Wickman Grant Raymond
  • Dixit Surjit Bhimarao
  • Escpbar-Cabrera Eric
  • Sanches Mario
RU2737882C2
SITE-SPECIFIC HER2 ANTIBODY-DRUG CONJUGATES 2016
  • Ma, Dangshe
  • Loganzo, Jr., Frank
  • Marquette, Kimberly Ann
  • Graziani, Edmund Idris
  • Sapra, Puja
  • Strop, Pavel
RU2745565C2
BIPARATOPIC FR-ALPHA ANTIBODIES AND IMMUNOCONJUGATES 2020
  • Eb, Olga
  • Kokhli, Niradzh
  • Chittenden, Tomas
  • Setiadi, Dzhulianto
RU2832083C2
SITE-SPECIFIC ANTIBODY-DRUG CONJUGATION BY GLYCOENGINEERING 2014
  • Pan, Clark
  • Zhou, Qun
  • Stefano, James
  • Dhal, Pradeep
  • Chen, Bo
  • Gianolio, Diego
  • Miller, Robert
  • Qiu, Huawei
RU2831409C2
ANTIBODIES AND ANTIBODY FRAGMENTS FOR SITE-SPECIFIC CONJUGATION 2016
  • Ma, Dangshe
  • Marquette, Kimberly Ann
  • Graziani, Edmund Idris
  • Sapra, Puja
  • Tumey, Lawrence Nathan
  • Prashad, Nadira Anarkali
  • Khandke, Kiran Manohar
  • Bennett, Eric M.
  • Tchistiakova, Lioudmila
RU2757815C2
CONJUGATES OF BINDER AND ACTIVE SUBSTANCE (ADC) HAVING ENZYMATICALLY CLEAVABLE GROUPS 2017
  • Lerkhen, Khans-Georg
  • Rebstok, Ann-Sofi
  • Shtelte-Lyudvig, Beatriks
  • Kirkhkhoff, Dennis
  • Ditts, Liza
  • Malert, Kristof
  • Greven, Zimone
  • Mersh, Shtefan
  • Berndt, Zandra
  • Zommer, Anette
  • Khammer, Shtefani
RU2761390C2
METHODS FOR PREPARING ANTIBODY-DRUG CONJUGATE COMPOSITIONS 2015
  • Pejn Dzhillian
  • Kherbst Robert V.
  • Bridzhuoter Dzhuma
RU2741470C2
ANTIBODY-STING AGONIST CONJUGATES AND USE THEREOF IN IMMUNOTHERAPY 2020
  • Chen, Zhijian
  • Shi, Heping
  • Wei, Qi
  • Chen, Chuo
  • Sun, Lijun
  • Qiu, Jian
  • Wu, Youtong
RU2826228C2
ANTIBODY-DRUG CONJUGATES BASED ON ERIBULIN AND APPLICATION METHODS 2017
  • Albone, Earl, F.
  • Cheng, Xin
  • Custar, Daniel, W.
  • Furuuchi, Keiji
  • Li, Jing
  • Majumder, Utpal
  • Uenaka, Toshimitsu
RU2754369C2
ANTI-HER2/ANTI-4-1BB BISPECIFIC ANTIBODY AND USE THEREOF 2020
  • Chung Hyejin
  • Yong Yeryoung
  • Park Kyeongsu
  • Park Eunyoung
  • Jung Ui-Jung
  • Lee Yangsoon
  • Kim Eunjung
  • Son Yong-Gyu
  • Son Wonjun
  • Ahn Seawon
  • Yeom Donghoon
  • Lee Chanmoo
  • Hong Junghyeon
  • Song Moo Young
  • Lee Eun-Jung
  • Lee Na Rae
  • Park Young Bong
  • Lee Eun-Jung
  • Kim Taewang
RU2831838C2

RU 2 806 049 C2

Authors

Hamblett, Kevin

Davies, Rupert H.

Rich, James R.

Rowse, Gerald J.

Fung, Vincent K. C.

Barnscher, Stuart D.

Dates

2023-10-25Published

2019-03-12Filed