NEW PHOSPHATE ETHER COMPOUND HAVING A PYRROLOPYRIMIDINE SKELETON, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF Russian patent published in 2023 - IPC C07H19/14 C07H1/00 A61K31/7064 A61P35/00 

FIELD: organic chemistry; pharmaceuticals.

SUBSTANCE: group of inventions is aimed at providing a new phosphate ester compound having a pyrrolopyrimidine skeleton and having an excellent antitumor effect. A compound which is: ((2R,3R,4S,5R)-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, or a pharmaceutically acceptable salt thereof are disclosed. Besides, the following is disclosed: an antitumor pharmaceutical composition, an agent that enhances the antitumor effect, a combined antitumor agent including an effective amount of the above compound as an active ingredient, methods of preventing or treating a tumor, including administering to a subject in need of it, the present compound including in combination with an alkylating agent or radiation therapy. Also the following use of 2R,3R,4S,5R)-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate or a pharmaceutically acceptable salt thereof for preventing or treating a tumor, for enhancing the antitumor effect of an alkylating agent, for producing an antitumor pharmaceutical composition or an antitumor agent is disclosed.

EFFECT: group of inventions provides effective antitumor treatment both in combination with an alkylating agent and/or radiation therapy.

48 cl, 9 dwg, 10 tbl, 14 ex