FIELD: medicine; pharmaceutics.
SUBSTANCE: first invention is the use of (S)-1-(3-(4-amino-3-((3,5-dimethoxyphenyl)ethynyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)pyrrolidine-1-yl)prop-2-en-1-one or its pharmaceutically acceptable salt for the treatment of a patient with cancer, receiving one or more additional compounds with an antitumor effect or their pharmaceutically acceptable salt(s), selected from 5-fluoruracil, tegafur/himeracil/potassium oteracil, gemcitabine, paclitaxel, cisplatin, everolimus, MK2206, and trans-3-amino-1-methyl-3-(4-(3-phenyl-5H-imidazo[1,2-c]pyrido[3,4-e][1,3]oxazine-2-yl)phenyl)cyclobutanol, gefitinib. The second invention is a method for the treatment of tumor, including the administration of the specified combinations to a patient who needs it.
EFFECT: group of inventions provides for a synergetic effect of antitumor combinations.
26 cl, 32 dwg, 4 tbl, 12 ex
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