PHARMACEUTICAL COMBINATION FOR CANCER TREATMENT Russian patent published in 2023 - IPC A61K31/201 A61K31/337 A61K31/555 A61K31/7068 A61K33/24 A61P35/00 

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to a pharmaceutical combination for the treatment of cancer in a human patient, comprising (A): a compound which is a polyunsaturated fatty acid of the formula COOH-CHOH-(CH₂)₆-(CH=CH-CH₂)₂-(CH₂)₃-CH₃(ABTL0812), its pharmaceutically acceptable salt, or a combination thereof, and (B): a compound which is a chemotherapeutic agent, where compound (B) is paclitaxel and the cancer is lung cancer, preferably non-small cell lung adenocarcinoma; compound (B) is carboplatin and the cancer is endometrial cancer; compound (B) is retinoic acid and the cancer is neuroblastoma; compound (B) is paclitaxel and the cancer is breast cancer, preferably triple negative breast cancer; compound (B) is paclitaxel and carboplatin, and the cancer is lung cancer; compound (B) is paclitaxel and carboplatin and the cancer is squamous cell carcinoma, preferably non-small cell squamous cell lung cancer; compound (B) is paclitaxel and carboplatin, and the cancer is non-small cell lung adenocarcinoma; compound (B) is cisplatin and pemetrexed, the cancer is lung cancer; compound (B) is cisplatin and pemetrexed and the cancer is non-small cell lung adenocarcinoma; compound (B) is paclitaxel and the cancer is endometrial cancer; compound (B) is paclitaxel and carboplatin, and the cancer is endometrial cancer; compound (B) is paclitaxel and gemcitabine, and the cancer is pancreatic cancer; compound (B) is nab-paclitaxel and gemcitabine, and the cancer is pancreatic cancer; compound (B) is doxorubicin and the cancer is breast cancer, preferably triple negative breast cancer; compound (B) is cisplatin and the cancer is neuroblastoma; or Compound (B) is cisplatin and gemcitabine and the cancer is cholangiocarcinoma.

EFFECT: invention provides a significant synergistic effect in the treatment of the above types of cancer with such a pharmaceutical combination.

10 cl, 17 dwg, 7 tbl, 4 ex