FIELD: pharmaceutical industry.
SUBSTANCE: invention relates to a process for the preparation of lenvatinib besylate salt in crystalline form 1, characterized by an X-ray powder diffraction pattern (XRPD) containing peaks at 4.9°, 11.2°, 17.1° and 24.6° degrees 2θ (±0.2 degrees 2θ) comprising suspending the free base of lenvatinib with benzenesulfonic acid in methanol or ethanol, bringing the mixture to reflux and cooling to isolate crystalline form 1 of the lenvatinib besylate salt.
EFFECT: obtaining a crystalline salt of lenvatinib besilate.
1 cl, 5 dwg, 2 tbl, 4 ex
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