FIELD; biotechnology; medicine.
SUBSTANCE: invention relates to the field of biotechnology and medicine. A test system for the diagnosis of M.tuberculosis complex infection is described, including a protein containing a combination of amino acid sequences encoded by the EsxA, EsxB, EspK, EspJ, tb7.7 (Rv2654c) genes. A method for diagnosing M.tuberculosis complex infection using a test system is also described. It involves the introduction of a whole blood sample into contact with an antigen, followed by incubation and quantitative immunochemical measurement of changes in the concentration of interferon gamma as a result of a specific reaction of circulating antigen-specific effector T-lymphocytes to a tuberculosis antigen preparation in M.tuberculosis complex sensitized patients.
EFFECT: technical result of using the invention is a group of antigens and a test system for screening diagnosis of tuberculosis infection, including those that do not have bright clinical manifestations.
4 cl, 2 dwg, 2 tbl, 6 ex
| Title |
Year |
Author |
Number |
| ALLERGEN CONTAINING COMBINATION OF PROTEIN SEQUENCES ENCODED BY M.TUBERCULOSIS COMPLEX EsxA, EsxB, EspJ, EspK GENES, AND METHOD FOR ITS APPLICATION FOR DIAGNOSIS OF MTUBERCULOSIS COMPLEX INFECTION |
2017 |
- Maksimov Nikolaj Lvovich
- Nacharova Elena Petrovna
- Savina Natalya Nikolaevna
|
RU2636490C1 |
| RECOMBINANT PLASMIDE ENCODING HYBRID GST-ESAT-6 POLYPEPTIDE HAVING ACTIVITIES OF SPECIES-SPECIFIC MYCOBACTERIAL ESAT-6 ANTIGEN, RECOMBINANT ESCHERICHIA COLI STRAIN AS PRODUCER OF HYBRID GST-ESAT-6 POLYPEPTIDE AND RECOMBINANT GST-ESAT-6 POLYPEPTIDE |
2004 |
- Tumanov Jurij Vasil'Evich
- Smirnova Ol'Ga Jur'Evna
- Boldyrev Aleksandr Nikolaevich
- Tat'Kov Sergej Ivanovich
|
RU2282661C2 |
| RECOMBINANT PLASMID DNA pTB232, WHICH CODES HYBRID POLYPEPTIDE GST-CFP10 WITH PROPERTIES OF SPECIES-SPECIFIC MYCOBACTERIAL ANTIGEN CFP10, RECOMBINANT STRAIN OF BACTERIA Escherichia coli-PRODUCER OF HYBRID POLYPEPTIDE GST-CFP10 AND RECOMBINANT POLYPEPTIDE GST-CFP10 |
2008 |
- Tumanov Jurij Vasil'Evich
- Smirnova Ol'Ga Jur'Evna
- Boldyrev Aleksandr Nikolaevich
- Tat'Kov Sergej Ivanovich
|
RU2381274C2 |
| RECOMBINANT PLASMID DNA pTB323 CODING HYBRID POLYPEPTIDE CST-DELTAMPT64 WITH PROPERTIES OF SPECIES-SPECIFIC MYCOBACTERIAL ANTIGEN MPT64 (MPB64), RECOMBINANT ESCHERICHIA COLI BACTERIAL STRAIN - PRODUCER OF HYBRID POLYPEPTIDE CST-DELTAMPT64 AND RECOMBINANT POLYPEPTIDE CST-DELTAMPT64 |
2011 |
- Tumanov Jurij Vasil'Evich
- Smirnova Ol'Ga Jur'Evna
- Boldyrev Aleksandr Nikolaevich
|
RU2458130C1 |
| TEST MODIFICATION METHOD FOR IN VITRO DIAGNOSIS OF TUBERCULOUS PLEURISY |
2019 |
- Vaneeva Tatyana Valerevna
- Kulikovskaya Neilya Vafinovna
- Abu Arkub Tamila Ismailovna
- Sinitsyn Mikhail Valerevich
- Safonova Svetlana Grigorevna
|
RU2708388C1 |
| DIAGNOSTIC TECHNIQUE FOR TUBERCULOSIS INFECTION |
2014 |
- Borodulin Boris Evgen'Evich
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- Borodulina Elena Aleksandrovna
- Akhmerova Tat'Jana Efimovna
- Titugina Anna Jur'Evna
|
RU2560679C1 |
| METHOD FOR IDENTIFYING BIOLOGICAL MARKERS DETECTED IN HUMAN BIOLOGICAL MATERIALS IN VIEW OF POSSIBLE PRESENCE OF PATHOLOGICAL CONDITIONS OF THE HUMAN BODY, INCLUDING ONCOLOGICAL DISEASES, IMPLEMENTED BY MEANS OF MULTIPLEX IMMUNOENZYME SANDWICH IMMUNOASSAY |
2021 |
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|
RU2779104C1 |
| POLYANTIGENIC VACCINE FOR PREVENTING AND ADJUNCTIVE TREATMENT OF TUBERCULOSIS |
2019 |
- Tkachuk Artem Petrovich
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|
RU2724896C1 |
| METHOD FOR IMMUNOLOGICAL DETERMINATION OF TUBERCULOSIS INFECTION ACTIVITY IN CHILDREN AND ADOLESCENTS WITH LATENT INFECTION |
2020 |
- Vladimirskij Mikhail Aleksandrovich
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|
RU2726789C1 |
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2013 |
- Tkachuk Artem Petrovich
- Ljashchuk Aleksandr Mikhajlovich
- Aksenova Ekaterina Ivanovna
- Poletaeva Nina Nikolaevna
- Galushkina Zoja Mikhajlovna
- Sergienko Ol'Ga Vasil'Evna
- Kondrat'Eva Tat'Jana Konstantinovna
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|
RU2546875C1 |
