FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to medicine and pharmaceutics and represents a recombinant tuberculosis vaccine comprising an effective amount of recombinant protein ESAT6-CFP10-Ag85a-Rv2660c, which is fused mycobacterial proteins ESAT-6, CFP10, Ag85a, Rv2660c with histidine tag with length of 8 residues, and an adjuvant represented by a CPG oligonucleotide and a muramyl dipeptide, wherein the recombinant protein and the adjuvant are immobilized on carrier particles from a lactic and glycolic acid copolymer PLGA.
EFFECT: increased immunogenic action of recombinant protein-antigen ESAT6-CFP10-Ag85a-Rv2660c in combination with adjuvant presented by CpG-ODN of class A and N-acetylmuramyl-L-alanyl-D-isoglutamine.
5 cl, 13 dwg, 10 tbl, 7 ex
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