RECOMBINANT CELL LINE TMDK562-15 SHOWING THE ABILITY TO ACTIVATE AND PROLIFERATE HUMAN NK CELLS Russian patent published in 2023 - IPC C12N5/10 C12N15/12 C12N15/24 C12N15/63 C12N15/85 

Abstract RU 2803178 C1

FIELD: biotechnology.

SUBSTANCE: present invention relates to a recombinant human myelogenous leukaemia cell line TMDK562-15, which has a surface expression of a membrane-bound form of a chimeric protein consisting of interleukin 15, a combination of CD215 sushi domain signalling molecules and TNFRSF9L (mbIL15sCD215TNFRSF9L).

EFFECT: invention is effective for activation and proliferation of natural killer cells (NK cells) during their co-culturing.

1 cl, 6 dwg, 3 ex

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RU 2 803 178 C1

Authors

Abakushina Elena Vyacheslavovna

Dates

2023-09-07Published

2022-12-08Filed