BIOMEDICAL CELL PRODUCT FOR TREATMENT OF MALIGNANT NEOPLASMS Russian patent published in 2024 - IPC C12N15/09 C12N15/81 A61P35/00 

Abstract RU 2813531 C1

FIELD: medicine; veterinary medicine.

SUBSTANCE: invention relates to the immunotherapy of malignant neoplasms using genetically modified lymphokine-activated killer cells (LAK cells) with a universal chimeric antigen T-cell receptor. The invention is CAR-LAK cells biomedical cell product with a universal T-cell receptor (CD16-CAR) characterized by CAR+CD25+CD3+ and CAR+CD16+CD56+ phenotype. The biomedical cell product is intended for the treatment of cancer patients in combination with monoclonal antibodies to tumour antigens.

EFFECT: invention makes it possible to obtain a biomedical cell product with antitumor activity regulated by monoclonal antibodies.

1 cl, 1 dwg, 2 ex

Similar patents RU2813531C1

Title Year Author Number
BIOMEDICAL CELL PRODUCT WITH ANTI-HER2 SPECIFIC ANTI-TUMOUR ACTIVITY 2019
  • Kiselevskij Mikhail Valentinovich
  • Petkevich Alisa Antonovna
  • Chikileva Irina Olegovna
  • Anisimova Natalya Yurevna
RU2728361C1
BIOMEDICAL CELL PRODUCT WITH SPECIFIC ANTITUMOR ACTIVITY, REPRESENTED BY POPULATIONS OF LYMPHOKINE-ACTIVATED KILLERS AND ANTI-HER2 CAR-γδΤ-OIL AND ANTI-HER2 CAR-T-NK 2022
  • Kiselevskij Mikhail Valentinovich
  • Petkevich Alisa Antonovna
  • Lipengolts Aleksej Andreevich
  • Chikileva Irina Olegovna
  • Anisimova Natalya Yurevna
RU2786210C1
PSCA-CAR-YT CELL LINE HAVING SURFACE EXPRESSION OF CHIMERIC ANTIGEN RECEPTORS AND EXHIBITING CYTOTOXIC ACTIVITY ON PSCA-POSITIVE HUMAN CANCER CELLS 2018
  • Matvienko Darya Aleksandrovna
  • Gorchakov Andrej Aleksandrovich
  • Kulemzin Sergej Viktorovich
  • Koval Olga Aleksandrovna
  • Volkova Olga Yurevna
  • Belovezhets Tatyana Nikolaevna
  • Chikaev Anton Nikolaevich
  • Smagina Anna Sergeevna
  • Tkachenko Anastasiya Viktorovna
  • Nushtaeva Anna Andreevna
  • Kuligina Elena Vladimirovna
  • Rikhter Vladimir Aleksandrovich
  • Taranin Aleksandr Vladimirovich
RU2712901C1
BIODEGRADABLE IMPLANT FOR LOCAL IMMUNOTHERAPY OF CANCER PATIENTS 2021
  • Anisimova Natalya Yurevna
  • Martynenko Natalya Sergeevna
  • Rybalchenko Olga Vladislavovna
  • Kiselevskij Mikhail Valentinovich
  • Mansharipova Almagul Tuleulovna
  • Kabieva Ajgul Odakovna
  • Dobatkin Sergej Vladimirovich
  • Estrin Yurij Zakharovich
RU2780932C1
BIODEGRADABLE METAL IMPLANT FOR LOCAL IMMUNOTHERAPY OF PATIENTS WITH SOLID TUMORS 2021
  • Anisimova Natalya Yurevna
  • Martynenko Natalya Sergeevna
  • Rybalchenko Olga Vladislavovna
  • Kiselevskij Mikhail Valentinovich
  • Mansharipova Almagul Tuleulovna
  • Kabieva Ajgul Odakovna
  • Dobatkin Sergej Vladimirovich
  • Estrin Yurij Zakharovich
RU2780927C1
METHOD FOR PRODUCING ANTI-TUMOR IMMUNOLOGICAL PROTECTION TO EL-4 LYMPHOMA CELLS 2018
  • Kazanskij Dmitrij Borisovich
  • Khromykh Lyudmila Mendelevna
  • Kalinina Anastasiya Andreevna
  • Silaeva Yuliya Yurevna
  • Zamkova Mariya Anatolevna
  • Bruter Aleksandra Vladimirovna
  • Persiyantseva Nadezhda Aleksandrovna
  • Chikileva Irina Olegovna
  • Dzholokhava Lejla Khvichaevna
RU2708558C1
TITANIUM IMPLANT WITH THE FUNCTION OF LOCAL IMMUNOTHERAPY FOR OSTEORECONSTRUCTIVE SURGERY AND PREVENTION OF LOCAL RECURRENCE OF ONCOLOGICAL DISEASE AND METHOD FOR ITS MANUFACTURE 2021
  • Straumal Boris Borisovich
  • Anisimova Natalya Yurevna
  • Kogtenkova Olga Aleksandrovna
  • Kiselevskij Mikhail Valentinovich
RU2779367C1
METHOD FOR DETERMINING MINIMAL RESIDUAL DISEASE BY MULTIPARAMETER FLOW CYTOMETRY IN CHILDREN AND ADULTS WITH B-LINEAR ACUTE LYMPHOBLASTIC LEUKEMIA IN CONDITIONS OF CD19-DIRECTED IMMUNOTHERAPY 2022
  • Mikhailova Ekaterina Valerevna
  • Popov Aleksandr Mikhailovich
  • Illarionova Olga Ivanovna
  • Semchenkova Aleksandra Aleksandrovna
  • Maschan Mikhail Aleksandrovich
  • Novichkova Galina Anatolevna
RU2818950C1
INSERTION OF TARGET GENE FOR IMPROVED CELLULAR IMMUNOTHERAPY 2017
  • Busser Brian
  • Duchateau Philippe
  • Juillerat Alexandre
  • Poirot Laurent
  • Valton Julien
RU2824204C2
METHOD FOR CREATION OF T-CELLS SUITABLE FOR ALLOGENEIC TRANSPLANTATION 2015
  • Puaro Loren
  • Surdive David
  • Dyushato Filipp
  • Kabanol Zhan-Perr
RU2752933C2

RU 2 813 531 C1

Authors

Kiselevskij Mikhail Valentinovich

Chikileva Irina Olegovna

Zamkova Mariya Anatolevna

Kazanskij Dimitrij Borisovich

Persiyantseva Nadezhda Aleksandrovna

Khromykh Lyudmila Mendelevna

Bruter Aleksandra Vladimirovna

Shatunova Polina Olegovna

Dates

2024-02-13Published

2023-05-02Filed