METHOD FOR PRODUCING CYCLIC ALKYLENE UREAS Russian patent published in 2023 - IPC C07D233/34 

FIELD: medical chemistry.

SUBSTANCE: method for producing a cyclic alkylene urea product of Formula I:

wherein a compound of Formula II and/or Formula III is contacted in a reaction zone with a compound of Formula IV and/or Formula V and in the presence of one or more carbonyl-delivering compounds,

in which R¹ represents -[AX-]_qR³; R² in each case is independently selected from H and C₁ to C₆ alkyl groups, which are optionally substituted by one or two groups selected from -OH and -NH₂; R³ in each case is independently selected from H and C₁ to C₆ alkyl groups, which are optionally substituted by one or two groups selected from -OH and -NH₂ ; A is in each instance independently selected from C₁ to C₃ alkylene units, optionally substituted with one or more C₁ to C₃ alkyl groups; X is in each case independently selected from -O-, -NR²-, a group of Formula VI and a group of Formula VII:

,

and p and q are each independently selected from an integer in the range 0-8. In this case, a compound of Formula II and/or a compound of Formula III is added to the reaction zone containing a compound of Formula IV and/or a compound of Formula V, continuously, semi-continuously or in two or more batches, and the carbonyl-delivering compound contains a carbonyl group transferred to the alkanolamine or alkylenediamine compound to form, respectively, a cyclic alkylene carbamate or a cyclic alkylene urea.

EFFECT: improved overall conversions and/or improved selectivity.

12 cl, 1 dwg, 5 tbl, 6 ex