METHOD OF INCREASING BONE MINERAL DENSITY IN PATIENTS WITH OSTEOPOROSIS AND POLYNEUROPATHY IN TYPE 2 DIABETES MELLITUS Russian patent published in 2023 - IPC A61M5/142 A61K39/395 A61K31/663 A61K33/10 A61P19/02 

FIELD: medicine; endocrinology; traumatology; rheumatology; therapy; geriatrics.

SUBSTANCE: combined sequential use of denosumab together with calcium preparations and vitamin D: colecalciferol or alfacalcidol is carried out. Besides, thioctic acid is used according to the following scheme 2 times a year: 600 mg — intravenously by drips 5 days a week for 4 weeks, followed by transfer to tablet intake of 600 mg 1 time per day in the morning 30 minutes before meals for 3 months. From the 3rd month of treatment, neurotropic vitamins are added to the therapy. The initial levels of the following vitamins are determined: B1, B6, B12. Afterwards, a course of 10 injections of neurotropic vitamins is performed. Then the patients are switched to their oral intake, with the control of the levels of vitamins B1, B6, B12 in dynamics.

EFFECT: method makes it possible to increase bone mineral density in patients with osteoporosis on the background of type 2 diabetes mellitus, reduce the frequency of fractures by reducing the number of falls in patients and expanding motor activity, and also improves the quality of life of patients.

1 cl, 1 ex, 1 dwg, 1 tbl