DEUTERIZED BENZIMIDAZOLE COMPOUND AND ITS MEDICAL USE Russian patent published in 2023 - IPC C07D235/08 C07D401/12 C07D405/06 A61K31/4184 A61K31/4439 A61K45/00 A61P13/02 A61P25/00 A61P25/04 A61P29/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition and a drug based on it for the treatment of a disease in which Nav 1.7 (SCN9A) is involved, selected from neuropathic pain, nociceptive pain, inflammatory pain, small fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria or multiple sclerosis, as well as a method of treating such diseases using it. In general formula (I), R^1a, R^1c and R^1d are hydrogen, R^1b is C₆ aryl, C₆ aryloxy or 6-membered heteroaryloxy, wherein the aryl and aryl group in aryloxy and the heteroaryl group in heteroaryloxy may be independently substituted with 1–2 substituents independently selected from the group consisting of halogen, C_1-4 alkyl optionally substituted with 1–3 substituents independently selected from Substituent Group A, and C_1-4 alkoxy optionally substituted with 1–3 substituents independently selected from Substituent Group A; R⁴ is hydrogen, m=0 or 1, L is CR⁷ R⁸, R⁷ and R⁸ are hydrogen; or R² and R³ are methyl or together with the carbon atom to which they are attached form a group of formula (II) with -OR⁴ ; in formula (II), e and f are 1, R⁴ is as defined above, V is an oxygen atom, R^5a, R^5b, R^5c and R^5d are hydrogen, Substituent Group A is independently halogen, and any 1–6 atoms of hydrogen in the compound of formula (I) may be replaced by deuterium atoms.

EFFECT: obtaining a deuterized benzimidazole compound.

11 cl, 5 ex