CEPHALOSPORIN ANTIBACTERIAL COMPOUND AND PHARMACEUTICAL USE THEREOF Russian patent published in 2024 - IPC C07D501/60 A61K31/546 A61P31/04 

FIELD: chemistry; pharmaceutics.

SUBSTANCE: invention relates to chemistry and pharmaceutics, specifically to a compound of formula (I-2), specific compounds specified below, pharmaceutically acceptable salts thereof, a pharmaceutical composition based thereon and their use for preparing a drug for preventing and treating a disease caused by gram-negative bacteria, which are E. coli, Klebsiella, Enterobacter, Pseudomonas aeruginosa and Acinetobacter. In general formula (I-2), X is CH; T is S; E is where each of R₁ and R₂ is independently selected from the group consisting of C₁-C₆ alkyl; F is a single bond; A is C₁-C₆ alkylene; is a quaternary ammonium group containing one or more N atoms and selected from the group consisting of a heterocyclyl containing from 5 ring atoms, where one ring atom is a heteroatom selected from nitrogen; G₂ is C₁-C₆ alkylene; C₂ is -NR₃₁-C(=O)-, where each R₃₁ is independently selected from the group consisting of C₁-C₆ alkyl and C₁-C₆ alkoxy, where each of alkyl and alkoxy is independently substituted with one or more substitutes selected from ; ring D₁ is phenyl; R_m is selected from phenyl, where phenyl is substituted with three substitutes selected from the group consisting of halogen and hydroxy, each R₄ is independently selected from halogen; n is 1; R_i is hydrogen. ,

.

EFFECT: cephalosporin antibacterial compound and its pharmaceutical use are disclosed.

6 cl, 1 tbl, 14 ex