FIELD: biotechnology.
SUBSTANCE: recombinant methods for the production of proteins used to obtain a recombinant bifunctional protein from a mammalian host cell. The method includes transformation of a host cell with a DNA vector expressing a bifunctional protein, and cultivation of the host cell in a culture medium supplemented with dextran sulfate.
EFFECT: stable production of the target protein by effectively preventing the decomposition of the target protein by the proposed method.
4 cl, 6 dwg, 7 tbl, 3 ex
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