METHOD FOR SCANNING BIOLOGICAL SUBSTANCES WITH THREE TYPES OF LOCALIZATION Russian patent published in 2023 - IPC G01N33/48 G06T7/00 G06N3/02 

FIELD: medicine.

SUBSTANCE: invention is related to methods for digitizing biological preparations using microscopic systems and neural networks and can be used to obtain information about the localization and classification of several smears located on one microscope slide. A method has been proposed for scanning smears of a biological specimen with three types of localization, which includes formation of a digital image of a slide with smears with obtaining an image of a macroscopic specimen by sequential photography at 2.5x magnification and stitching of the resulting images, formation of an image of a microscopic specimen by compression and stitching, input of an image of a microscopic specimen into the first pre-trained neural network to obtain a set of stroke masks, which are divided into fields of view and into angular sectors, selection of the best fields of view in each sector and digitizing of the best field of view in each sector of each localization at a high magnification of 100x, using the scalar product to calculate the angle α between X axis and vector from the origin to the center of the field of view according to a mathematical formula. Next, the visual fields with the highest scores are marked as preferred, the coordinates of which are stored in the computer memory, and the locations of strokes of three different localizations are determined.

EFFECT: invention enables scanning of smears of a biological preparation with three different types of localization and determination of the location of smears of different localizations.

1 cl, 7 dwg, 1 tbl