METHOD FOR TREATING PREDIABETES IN PERSONS WITH EXTERNAL EATING BEHAVIOR Russian patent published in 2023 - IPC A61B5/00 A61K31/175 A61K31/4045 A61K31/10 A61P3/04 

FIELD: medicine.

SUBSTANCE: invention is related to internal diseases, therapy, endocrinology, and concerns the treatment of prediabetes. The method includes diet therapy with a reduced calorie content of 1200 kcal for women and 1500 kcal for men with a restriction of carbohydrate-containing foods and fats; the diet includes carbohydrate-containing foods with a glycaemic index of less than 40. When the initial body weight decreases by 5% and the weight stabilizes within 2 months, the caloric intake is raised to the calculated value determined for the patient using the formula for calculating daily caloric intake recommended by WHO, taking into account gender, age, height, weight and physical activity. At the same time, carbohydrate-containing foods with a glycaemic index of 40-69 are introduced into the diet until weight is reduced to a given level. From the first day of treatment, extended-release metformin is prescribed once a day at a dose of 500 mg in the evening for 2 weeks, then at a dose of 1000 mg, and extended-release metformin is continued for another 12 months. Additionally, the external type of eating behaviour is assessed using the DEBQ questionnaire, which includes 10 questions, the answers to which are assessed on a six-point scale, where “never” is 0 points, “rarely” - 1 point, “sometimes” - 2 points, “often” - 3 points, “very often” - 4 points, “always” - 5 points. With a score of over 2.68, an external type of eating behaviour is identified. From the first day of treatment, Melaxen is administered at night for 30 minutes before bedtime at a dose of 3 mg during the first week, then at a dose of 4.5 mg over the next 6 months, then at a dose of 3 mg over the next 3 months, then at dose of 3 mg during the first 15 days of each month, for another 3 months. From the beginning of treatment, the drug Dibicor is prescribed at a dose of 500 mg 2 times a day 20 minutes before meals for 3 months. Moreover, after 6 months, the course of treatment with Dibicor at a dose of 500 mg 2 times a day 20 minutes before meals for 3 months is repeated again.

EFFECT: invention makes it possible to achieve faster and more significant reduction in the level of fasting and postprandial hyperglycaemia, insulin resistance, normalization of lipid metabolism, formation of rational eating behaviour and modification of behavioural risk factors, reduce emotional discomfort, increase the body's adaptive mechanisms to stress reactions, by restoring the circadian rhythms of melatonin secretion, leading to an increase in the therapeutic effect of treatment in people with prediabetes who have an external type of eating behaviour.

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