VARIANT CD3 BINDING DOMAINS AND THEIR USE IN COMBINATION THERAPY FOR TREATMENT OF DISEASES Russian patent published in 2023 - IPC C07K16/28 C07K16/30 A61K39/395 A61P35/00 

Abstract RU 2810222 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to a binding molecule specific to a disease-related antigen and CD3, as well as to a composition containing it.

EFFECT: invention is effective for the treatment of a disease associated with B7-H3, CEACAM5/CEACAM6, EGRF, EphA2, gpA33, HER2/neu, VEGF, 5T4, IL13Rα2 or CD19.

21 cl, 36 dwg, 20 tbl, 13 ex

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RU 2 810 222 C2

Authors

Bonvini, Etsio

Khuan, Lin

Lam, Chia-In Kao

Chichili, Gurunad Reddi

Alderson, Ralf Froman

Mur, Pol A.

Dzhonson, Lesli S.

Dates

2023-12-25Published

2019-02-13Filed