ANTIBODY-STING AGONIST CONJUGATES AND USE THEREOF IN IMMUNOTHERAPY Russian patent published in 2024 - IPC A61K47/68 A61P35/00 

Abstract RU 2826228 C2

FIELD: chemistry.

SUBSTANCE: invention relates to antibody-drug conjugates containing a cyclic dinucleotide of formula IIk, which is a STING agonist, conjugated with an antibody, methods for preparing them and using them.

EFFECT: antibody-sting agonist conjugates and their use in immunotherapy are disclosed.

39 cl, 5 dwg, 4 tbl, 7 ex

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RU 2 826 228 C2

Authors

Chen, Zhijian

Shi, Heping

Wei, Qi

Chen, Chuo

Sun, Lijun

Qiu, Jian

Wu, Youtong

Dates

2024-09-06Published

2020-07-20Filed