FIELD: organic chemistry; pharmaceuticals.
SUBSTANCE; group of inventions is related to catecholamine-based prodrugs for use in treatment of neurodegenerative diseases and disorders. A compound of formula (Id), wherein R1 is H and R2 is selected from one of substituents (i) and (ii); or R1 is selected from one of substituents (i) and (ii) below, and R2 represents H; or R1 and R2 are simultaneously represented by substituent (i) below; or R1 and R2 are simultaneously represented by substituent (ii) below; or R1 is substituent (i) and R2 is substituent (ii); or R1 is substituent (ii) and R2 is substituent (i); where * denotes the attachment point; and the carbon atom at the point of attachment at the substituent (i) is in the S-configuration; or a pharmaceutically acceptable salt thereof, are disclosed. In addition, a pharmaceutical composition having dopamine agonist activity and containing a therapeutically effective amount of the above compound, methods for treating a neurodegenerative and neuropsychiatric disease, and in addition, the use of the compound Id for the treatment of diseases and for production of a medicinal product are disclosed.
EFFECT: group of inventions provides effective treatment of neurodegenerative diseases through prodrug compounds with optimal pharmacokinetic profiles.
23 cl, 8 dwg, 4 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL SOLID FORMS (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID | 2020 |
|
RU2820501C2 |
| METHOD OF PRODUCING (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND INTERMEDIATE COMPOUNDS FOR ITS PRODUCTION | 2020 |
|
RU2817700C2 |
| METHOD OF PRODUCING (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID | 2020 |
|
RU2819919C2 |
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