METHOD OF PRODUCING (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND INTERMEDIATE COMPOUNDS FOR ITS PRODUCTION Russian patent published in 2024 - IPC C07D405/12 C07H1/00 C07H13/02 C07H13/10 A61K31/473 A61P25/00

Abstract RU 2817700 C2

FIELD: chemical or physical processes.

SUBSTANCE: invention relates to a method of producing a compound of formula (Id) or a pharmaceutically acceptable salt thereof from compound (I), where said method involves reaction of compound (A2) with (2S,3S,4S,5R,6R)-2-(methoxycarbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyltriacetate in aprotic solvent in the presence of a Lewis acid to obtain compound (A3) and a step for removing the protective group from compound (A3) using a nucleophilic reagent. Invention also relates to a compound of formula (A3) or a salt thereof and use of the compound of formula (A3) in a method of producing the compound of formula (Id).

EFFECT: obtaining a compound of formula (Id) with high output.

14 cl, 9 dwg, 3 tbl, 12 ex

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RU 2 817 700 C2

Authors

Dzhukhl, Martin

Yakobsen, Mikkel,Fog

Kvaerno, Lisbet

Dates

2024-04-18—Published

2020-05-19—Filed