FIELD: organic; medicinal chemistry.
SUBSTANCE: invention relates to the use of substituted (E)-8-(2-oxo-2-R-ethylidene)-2-R1-3-R2-6-R3-pyrrolo[1,2-a]thieno[3,2-e]pyrimidine-4,7(5H,8H)-diones of general formula 1 a-d in medicine as anticancer agents in the treatment of lung melanoma.
1: R = Ph, R1+R2 = -(CH2)6-, R3 = COOEt (a);
R = Ph, R1+R2 = -(CH2)6-, R3 = CN (b);
R = Ph, R1+R2 = -(CH2)5-, R3 = CONH2 (c);
R = 4-MeOC6H5, R1+R2 = -(CH2)5-, R3 = CN (d).
EFFECT: possibility of using substituted (E)-8-(2-oxo-2-R-ethylidene)-2-R1-3-R2-6-R3-pyrrolo[1,2-a]thieno[3,2-e]pyrimidine-4,7(5H,8H)-diones as effective anticancer agents in the treatment of lung melanoma with low toxicity to healthy tissues.
1 cl, 1 tbl, 6 ex
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Year |
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