FIELD: organic chemistry.
SUBSTANCE: invention relates to organic and medical chemistry, to novel biologically active substances of the class of substituted pyrrolo[4,5-a]thieno[3,2-e]pyrimidines, specifically to (E)-5-amino-2-oxo-1-((E)-2-oxo-4-phenylbut-3-en-1-ylidene)-1,2,6,7,8,9-hexahydrobenzo[4,5]thieno[3,2-e]pyrrolo[1,2-a]pyrimidine-3-carboxamide of formula 1.
EFFECT: substance has anticancer activity in the therapy of pulmonary melanoma, which enables its use in medicine as drugs with cytotoxic properties and low toxicity.
1 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| (E)-5-AMINO-2-OXO-1-(2-(NAPHTHALEN-2-YL)-2-OXOETHYLIDENE)-1,2,6,7,8,9-HEXAHYDROBENZO[4,5]THIENO[3,2-E]PYRROLO[1,2-A]PYRIMIDINE-3-CARBOXAMIDE, HAVING ANTICANCER ACTIVITY IN BREAST CANCER THERAPY |
2023 |
- Karpov Timofei Evgenevich
- Rogova Anna
- Timin Aleksandr Sergeevich
- Shipilovskikh Sergei Aleksandrovich
|
RU2820661C1 |
| USE OF CYTOTOXIC AGENTS BASED ON SUBSTITUTED (E)-8-(2-OXO-2-R-ETHYLIDENE)-2-R1-3-R2-6-R3-PYRROLO[1,2-a]THIENO[3,2-e]PYRIMIDINE-4,7(5H,8H)-DIONES IN THE TREATMENT OF LUNG MELANOMA |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Timin Aleksandr Sergeevich
|
RU2808534C1 |
| SUBSTITUTED ETHYL ESTERS (E)-2-(5-AMINO-4-R1-3-OXO-2-(2-OXO-2-(P-TOLYL)ETHYLIDENE)-2,3-DIHYDRO-1H-PYRROL- 1-YL)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[b]THIOPHENE-3-CARBOXYLIC ACID, WHICH HAS ANTICANCER ACTIVITY IN THE TREATMENT OF LUNG MELANOMA |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Timin Aleksandr Sergeevich
|
RU2806324C1 |
| USE OF CYTOTOXIC AGENTS BASED ON SUBSTITUTED POTASSIUM 1-AMINO-1,6-DIOXO-2-CYANO-1-ETHOXY-6-R1-4-[((3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-yl)AMINO]HEXA-2,4-DIEN-3-OLATES IN TREATMENT OF LUNG MELANOMA |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Timin Aleksandr Sergeevich
|
RU2808533C1 |
| 5-AMINO-1-(2-OXO-2-PHENYLETHYLIDENE)-3-(PYRROLIDINE-1-CARBONYL)-6,7,8,9-TETRAHYDROBENZO[4,5]THIENO[3,2-e]PYRROLO[1,2-a]PYRIMIDIN-2(1H)-ONE, WHICH HAS ANALGESIC ACTIVITY |
2023 |
- Parkhoma Kseniia Iurevna
- Lipin Dmitrii Vladimirovich
- Makhmudov Ramiz Ragibovich
- Shipilovskikh Sergei Aleksandrovich
|
RU2810252C1 |
| AMIDE (E)-2-AMINO-4-OXO-5-(2-OXO-2-PHENYLETHYLIDENE)-1-(3-ETHOXYCARBONYL)-4,5,6-7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID, HAVING ANTIMICROBIAL ACTIVITY |
2020 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Tkachenko Aleksandr Georgievich
- Nesterova Larisa Yurevna
|
RU2738405C1 |
| ETHYL ETHER OF 2-(((Z)-AMINO((Z)-2,4-DIOXO-5-(2-OXO-2-PHENYLETHYLIDENE)PIRROLIDINE-3-YLIDEN)METHYL)AMINO)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENCARBOXYLIC ACID WITH ANALGETIC ACTIVITY |
2016 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Vasileva Anastasiya Yurevna
|
RU2631649C1 |
| 2-AMINO-1-BENZAMIDO-5-[2-(NAPHTHALENE-1-YL)-2-OXOETHYLIDENE]-4-OXO-4,5-DIHYDRO-1H-PYRROLE-3-CARBOXAMIDE EXHIBITING CYTOTOXIC AND PROAPOPTOGENIC PROPERTIES AGAINST HUMAN SOLID TUMOUR CELLS, INCLUDING THOSE RESISTANT TO CHEMOTHERAPEUTIC AGENTS |
2020 |
- Bojchuk Sergej Vasilevich
- Igidov Nazim Musabekovich
- Zykova Svetlana Sergeevna
- Galembikova Ajgul Rafikovna
- Aukhadieva Aida Maratovna
- Bikinieva Firyuza Fanisovna
- Nurgatina Ilmira Ilyazovna
- Gankova Kseniya Leonidovna
- Shustov Maksim Vadimovich
|
RU2753479C1 |
| 2-AMINO-1-BENZAMIDO-5-(3,3-DIMETHYL-2-OXOBUTYLIDENE)-4-OXO-4,5-DIHYDRO-1H-PYRROL-3-CARBOXAMIDE CAUSING IRREGULARITIES IN THE PHASES OF THE CELL CYCLE AND EXHIBITING CYTOTOXIC ACTIVITY AGAINST SOFT TISSUE SARCOMAS AND GASTROINTESTINAL STROMAL TUMOURS (GIST) |
2020 |
- Zykova Svetlana Sergeevna
- Bojchuk Sergej Vasilevich
- Igidov Nazim Musabekovich
- Galembikova Ajgul Rafikovna
- Aukhadieva Aida Maratovna
- Bikinieva Firyuza Fanisovna
- Nurgatina Ilmira Ilyazovna
- Gankova Kseniya Leonidovna
- Shustov Maksim Vadimovich
|
RU2765545C1 |
| ETHYL ETHER 2-AMINO-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)-5-(2-(4-ETHYLPHENYL)-2-OXOETHYLIDENE)-4-OXO- 4,5-DIHYDRO-1H-PYRROL-3-CARBOXYLIC ACID WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
- Parkhoma Kseniia Iurevna
|
RU2810070C1 |
