FIELD: organic chemistry; medical chemistry.
SUBSTANCE: invention relates to novel biologically active substances of the class of substituted pyrrolo[4,5-a]thieno[3,2-e]pyrimidines, specifically to (E)-5-amino-2-oxo-1-(2-(naphthalen-2-yl)-2-oxoethylidene)-1,2,6,7,8,9-hexahydrobenzo[4,5]thieno[3,2-e]pyrrolo[1,2-a]pyrimidine-3-carboxamide of formula 1, used as an anticancer agent in breast cancer therapy.
EFFECT: obtaining a compound of a number of substituted pyrrolo[4,5-a]thieno[3,2-e]pyrimidines with pronounced anticancer activity in therapy of breast cancer and low toxicity with respect to healthy tissues.
1 cl, 2 tbl, 3 ex
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Year |
Author |
Number |
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