NEW SULPHONAMIDE CARBOXAMIDE COMPOUNDS Russian patent published in 2023 - IPC C07D205/04 C07D205/12 C07D207/12 C07D211/54 C07D211/96 C07D215/36 C07D217/22 C07D223/06 C07D233/06 C07D239/60 C07D239/66 C07D241/18 C07D401/04 C07D401/06 C07D401/12 C07D401/14 C07D403/04 C07D403/06 C07D405/04 C07D405/06 C07D409/04 C07D451/02 C07D451/14 C07D453/02 C07D471/08 A61K31/64 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of Formula I that can inhibit NLRP3 and may find use in the treatment or prevention of a disease, disorder or condition responsive to NLRP3 inhibition. In formula, I Q represents O; R¹ represents a non-aromatic heterocyclic group selected from, wherein R¹ is attached to the sulfur atom of the sulfonylurea group via a ring carbon atom and where R¹ may optionally be substituted by one or more substituents independently selected from -R^β; -OR^β; -SO₂R^β; -COR^β; -COOR^β; -R^α-COOR^β; -CONHR^β; -CON(R^β)₂; -R^α-CON(R^β)₂;;; oxo (=O) or C₁-C₄ alkylene bridge; where each -R^α is independently selected from an alkylene group containing from 1 to 6 carbon atoms in its skeleton; where each -R^β is independently selected from a C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl or C₃-C₇ cycloalkyl group, or a 3–7 membered heterocyclic group containing one heteroatom selected from N, O or S, and any -R^β may be optionally substituted with one or more C₁-C₃ alkyl, C₁-C₃ haloalkyl, C₃-C₇ cycloalkyl, -O(C₁-C₃ alkyl), halogen, -CN, -C≡CH or oxo (=O); where each -R^δ is independently selected from a C₁-C₆ alkyl group; where each m is independently selected from 1 or 2; where each n is independently selected from 1 or 2; and R² represents .

EFFECT: invention also relates to various pharmaceutically acceptable salts of the said compound, a pharmaceutical composition containing them, their use in the manufacture of a medicinal product for treating or preventing a disease, disorder or condition responsive to NLRP3 inhibition, a method of treating such diseases and a method of inhibiting NLRP3.

26 cl, 3 tbl, 195 ex